The title refers to the hospital where JFK was pronounced dead, his assassin Lee Harvey Oswald, died two days later, and Oswald's killer Jack Ruby died several years after that.
Efron will play a Doctor who was working in the ER Whle Harden plays a Nurse.
James Badge Dale was cast to play Robert Edward Lee Oswald, Jr., the brother of the killer. earlier this month. Paul Giamatti, Billy Bob Thornton and Jacki Weaver also star.
Writer Peter Landesman is set to make his directorial debut on the film which chronicles the fateful day and private citizen Abraham Zapruder's famous film of the event. Landesman also penned the adapted screenplay from a book by the famed Vincent Bugliosi
Tom Hanks and Gary Goetzman are set to produce the pic.
The project will film in Austin, Texas soon for release next year in time for the 50th anniversary of the shooting.
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